Deubiquitinating enzymes (DUBs) are proteases that control the post-translational modification of proteins by ubiquitin and in turn regulate diverse cellular pathways.Despite a growing understanding of DUB biology at the structural and molecular level, little is known about the physiological importance of most DUBs.Here, we systematically identify
Mustafa Syed,1–3 Jakob Liermann,1–3 Vivek Verma,4 Denise Bernhardt,1,2 Nina Bougatf,1,3 Angela Paul,1,2 Stefan Rieken,1–3 Jürgen Debus,1–3,5 Sebastian Adeberg1,2,5 1Heidelberg Institute of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; 2Department of Radiation Oncology, University Hospital Heide
This publication presents selected aspects of the demographic development of East Germany based on the Bedside Crib example of the state of Mecklenburg-Vorpommern, which after the reunification of Germany in 1990 found itself in a new socio-economic situation.The main goal of the study was to recognize the mechanisms, regularities and directions of
High-starch diets (HSDs) fed to high-producing ruminants are often responsible for rumen dysfunction and could impair animal health and production.Feeding HSDs are often characterized by transient rumen pH depression, accurate monitoring of which requires costly or invasive methods.Numerous clinical signs can be followed to monitor such diet change